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KMID : 0869620160330020122
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Journal of Korean Society of Hospital Pharmacists
2016 Volume.33 No. 2 p.122 ~ p.129
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Evaluation of Drug-Drug Interaction in Pediatric Intensive Care Unit
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Kim Ji-Na
Park Hyo-Jung
Pakr Su-Jin
In Yong-Won
Lee Young-Mee
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Abstract
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Purpose : The aim of this study was to describe the frequency and severity of potential drug-drug interactions (pDDIs) in pediatric intensive care unit and evaluate the congruence in severity rating between Micromedex?? (TRUVEN health analytics) and Lexicomp Online?? (Wolters Kluwer).
Methods : This study was conducted in pediatric intensive care unit of Samsung Medical Center between January and May 2015. Electronic medical records of 59 patients were retrospectively reviewed for pDDIs using Micromedex??
Results : A total of 312 pDDIs were identified, and according to severity, 2.6% were contraindicated, 43.6% major, 49.4% moderate and 4.4% minor. The most frequent pDDIs included fentanyl-ranitidine (2.9%), fentanyl-midazolam (2.2%), and captopril-furosemide (1.6%). The most involved therapeutic group was immunosuppressant (9.9%) and the most frequently involved drug was cyclosporine (7.7%). Micromedex?? and Lexicomp Online?? were in agreement on the severity ratings in 42.6% of pDDIs.
Conclusion : Various types of pDDIs in the pediatric intensive care unit were recorded. A minimum of two references are required for the identification of pDDIs.
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KEYWORD
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Drug-drug interaction, Pediatric intensive care unit, Micromedex, Lexicomp Online
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